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Background: Phosphatase and tensin                            

homolog (PTEN) was identified as a 

tumor suppressor that is mutated in a 

large number of cancers at high 

frequency. It is one of the most commonly 

lost tumor suppressors in human cancer. 

During tumor development, mutations and 

deletions of PTEN occur that inactivate its 

enzymatic activity leading to increased cell 

proliferation and reduced cell death. 

Frequent genetic inactivation of PTEN occurs 

in glioblastoma, endometrial cancer, and 

prostate cancer; and reduced expression is 

found in many other tumor types such as 

lung and breast cancer.

Immunogen: A synthetic peptide from the 

internal region of PTEN which includes the 

mutation of R159S, human origin.

Tested applications: ELISA, WB

Recommended dilutions:

ELISA:  1:1000-1:5000

WB:     1:500-1:1000

IHC:     1:50-1:100

Concentration: 1 mg/ml

Host: Mouse

Clonality: Monoclonal

Purity: Purified from ascites

Format: Liquid

Storage buffer: 

Preservative: no

Constituents: PBS (without Mg2+ and Ca2+), 

pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Recognizes EGFR 

(L747-P753) S, but not wild type EGFR 

protein from vertebrates.

Storage Conditions: Store at -20°C. Avoid 

freeze / thaw cycles.